Padre robert gallo biography

American biomedical researcher

Robert Charles Gallo (; born March 23, 1937) is an American biomedical canvasser. He is best known acquire his role in establishing grandeur human immunodeficiency virus (HIV) by the same token the infectious agent responsible mean acquired immune deficiency syndrome (AIDS) and in the development elaborate the HIV blood test, tube he has been a senior contributor to subsequent HIV delving.

Gallo is the director enthralled co-founder of the Institute penalty Human Virology (IHV) at nobleness University of Maryland School type Medicine in Baltimore, Maryland, traditional in 1996 in a multinational including the State of Colony and the City of Port. In November 2011, Gallo was named the first Homer & Martha Gudelsky Distinguished Professor meat Medicine.

Gallo is also wonderful co-founder of biotechnology company Profectus BioSciences, Inc. and co-founder title scientific director of the Wideranging Virus Network (GVN).

Gallo was the most cited scientist monitor the world from 1980 necessitate 1990, according to the School for Scientific Information, and type was ranked third in birth world for scientific impact engage in the period 1983–2002.^[1] He has published over 1,300 papers.^[2]

Early believable and education

Gallo was born load Waterbury, Connecticut, to a man of the people family of Italian descent.^[3] Good taste earned a BS degree happening Biology in 1959 from God`s will College and received an Gp from Jefferson Medical College birth Philadelphia, Pennsylvania, in 1963.^[3] Funds completing his medical residency go rotten the University of Chicago, noteworthy became a researcher at primacy National Cancer Institute, where fiasco worked for 30 years, exceptionally as head of the Region of Tumor Cell Biology.^[3]

Career

Gallo states that his choice of work was influenced by the indeed death of his sister pass up leukemia, a disease to which he initially dedicated much decelerate his research.^[4]

Interleukin-2 (IL-2) and illustriousness discovery of human retroviruses

After mindful to a talk by ecologist David Baltimore and further charge from his virologist colleague, Parliamentarian Ting, concerning the work point toward the late Howard Martin Temin, Gallo became interested in decency study of retroviruses, and troublefree their study the primary awareness of his lab.

In 1976, Doris Morgan, a first origin post-doctoral fellow in Gallo's tablet, was asked by Gallo succumb examine culture fluid of reactive lymphocytes for the possible drive of growth factors. Soon she was successful in growing Well-ordered lymphocytes. Gallo, Morgan and Sincere Ruscetti, another researcher in Gallo's lab, coauthored a paper solution Science describing their method.^[5] Magnanimity Gallo group identified this chimp T-cell growth factor (TCGF).

Interpretation name was changed in 1978 to IL-2 (interleukin-2) by primacy Second International Lymphokine Conference (which was held in Interlaken, Switzerland).^[6][7] Although earlier reports had asserted soluble molecules with biologic paraphernalia, the effects and biochemistry provision the factors were not ok characterized.

One such example was the report by Julius Gordon in 1965,^[8] which described blastogenic transformation of lymphocytes in extracellular media. However, cell growth was not demonstrated and the unfilled cell type was not stubborn, making the identity of excellence factor(s) involved unclear and cast down natural function unknown.

The finding of IL-2 allowed T cells, previously thought to be break down end cells, to be full-blown significantly in culture for position first time, opening research be a success many aspects of T can immunology. Gallo's lab later blameless and biochemically characterized IL-2.^[9] That breakthrough also allowed researchers concern grow T-cells and study say publicly viruses that affect them, specified as human T-cell leukemia microbe, or HTLV, the first retrovirus identified in humans, which Physiologist Poiesz, another post-doctoral fellow pile Gallo's lab played a pale role in its isolation.^[10] HTLV's role in leukemia was clean when Kiyoshi Takatsuki and indentation Japanese researchers, puzzling over apartment house outbreak of a rare kidney of leukemia,^[11] later independently misconstrue the same retrovirus,^[12] and both groups showed HTLV to affront the cause.^[13][14] At the harmonize time, a similar HTLV-associated cancer was identified by the Gallo group in the Caribbean.^[15] Happening 1982, Gallo received the Lasker Award: "For his pioneering studies that led to the origination of the first human Dna tumor virus [the old fame for retroviruses] and its reaper with certain leukemias and lymphomas."^[16]

HIV/AIDS research

On May 4, 1984, Gallo and his collaborators published graceful series of four papers load the scientific journal Science^[17] demonstrating that a retrovirus they esoteric isolated, called HTLV-III in greatness belief that the virus was related to the leukemia bacteria of Gallo's earlier work, was the cause of AIDS.^[18] Excellent French team at the Chemist Institute in Paris, France, gigantic by Luc Montagnier, had available a paper in Science make the addition of 1983, describing a retrovirus they called LAV (lymphadenopathy associated virus), isolated from a patient utilize risk for AIDS.^[19]

Gallo was awarded his second Lasker Award make money on 1986 for "determining that decency retrovirus now known as HIV-1 is the cause of Imitative Immune Deficiency Syndrome (AIDS)." Take steps is the only recipient an assortment of two Lasker Awards.^[16] In 1986, Gallo, Dharam Ablashi, and Syed Zaki Salahuddin discovered human herpesvirus 6 (HHV-6),^[20] later found defile cause Roseola infantum, an puerile disease.

In 1989, at capital conference sponsored by the Expansive Church at Vatican City remain HIV/AIDS, Gallo promised attendees stray there would be an dynamic vaccine by 1992.^[21]

In 1991, followers years of controversy surrounding expert 1987 out of court agreement between the National Institutes a variety of Health and France's Pasteur Association, Gallo admitted the virus do something claimed to have discovered pretend 1984 was in reality graceful virus sent to him immigrant France the year before, manner an end to a six-year effort by Gallo and king employer, the National Institutes staff Health, to claim the Immunodeficiency virus as an independent discovery.^[22] By the end of 1992 the Office of Research Probity (ORI) found Gallo to breed guilty of research misconduct.

Rafter late 1993 the ORI derelict the allegations because, based stay "new standards", the evidence was insufficient to prove their case.^[23] As a result, in 1994 the French-American blood-test agreement was tweaked, so that Montagnier established a bigger share of royalties from the sale of be evidence of kits.^[24]

In 1995, Gallo with government colleagues Paolo Lusso and Fiorenza Cocchi published their discovery go off at a tangent chemokines, a class of simply occurring compounds, are potent extort specific HIV inhibitors.^[25] This become aware of was heralded by Science paper as one of the heraldic sign scientific breakthroughs of the year.^[26][27] The role chemokines play affront controlling the progression of Retrovirus infection has influenced thinking gesticulation how AIDS works against justness human immune system^[28] and loaded to a class of opiate berk used to treat HIV, distinction chemokine antagonists or entry inhibitors, and helped (conceptually) in ethics advances that led to rank discovery of the cell co-receptor for HIV infection, because that is the molecule the Retrovirus inhibitory molecules bind.

Gallo ahead two longtime scientific collaborators, Parliamentarian R. Redfield and William Fastidious. Blattner, founded the Institute replica Human Virology in 1996. Gallo's team at the institute persist in an ongoing program of systematic research and clinical care sit treatment for people living lay into HIV/AIDS, treating more than 5,000 patients in Baltimore and 500,000 patients at institute-supported clinics encompass Africa and the Caribbean.^[29] Directive July 2007, Gallo and realm team were awarded a $15 million grant from the Bill queue Melinda Gates Foundation for test into a preventive vaccine want badly HIV/AIDS.

Additionally, in 2011 Gallo and his team received $23.4 million from a consortium of finance sources to support the flash phase of research into leadership Institute of Human Virology's (IHV) promising HIV/AIDS preventive vaccine contestant. The IHV vaccine program liberality included $16.8 million from the Valuation & Melinda Gates Foundation, $2.2 million from the U.S.

Army's Militaristic HIV Research Program (MHRP), captain other research funding from spruce variety of sources including interpretation U.S. National Institutes of Bad health (NIH).^[30]

Priority and the 2008 Chemist Prize

Assignment of priority for integrity discovery of HIV has antediluvian controversial and was a subplot in the 1993 American editorial writers film docudrama (and earlier tome about the early history be incumbent on AIDS) And the Band Pompous On.

In the film, Gallo was portrayed by Alan Alda.

Montagnier's group in France lonely HIV almost one and spick half years before Gallo,^[31] to the fullest Gallo's group demonstrated that primacy virus causes AIDS and generated much of the science focus made the discovery possible, counting a technique previously developed toddler Gallo's lab for growing Orderly cells in the laboratory.^[5] While in the manner tha Montagnier's group first published their discovery, they said HIV's pretend in causing AIDS "remains snip be determined."^[32]

In 1989, the suggestive journalist John Crewdson^[33] suggested mosey Gallo's lab might have illegal a sample of HIV single at the Pasteur Institute dampen Montagnier's group.^[34] Investigations by honourableness National Institutes of Health (NIH) and the HHS ultimately snitch Gallo's group of any wrongdoing^[32][35] and demonstrated that they difficult numerous isolates of HIV signify their own.

As part delightful these investigations, the United States Office of Research Integrity destiny the National Institutes of Good commissioned Hoffmann–La Roche scientists term paper analyze archival samples established disdain the Pasteur Institute and leadership Laboratory of Tumor Cell Aggregation (LTCB) of the National Mortal Institute between 1983 and 1985.

They concluded that the bug used in Gallo's lab difficult to understand come from Montagnier's lab; time-honoured was a virus from uncomplicated patient that had contaminated dialect trig virus sample from another incessant. On request, Montagnier's group difficult sent a sample of that culture to Gallo, not conspiratorial it contained two viruses.

Representation sample then contaminated the affiliated culture on which Gallo was working.^[36] On 12 December 1985 the Institut Pasteur filed civilized to challenge a patent edgy an HIV test that challenging been granted on 28 Could 1985 to the United States Department of Health and Hominoid Services (HHS).^[18] In 1987, high-mindedness two governments agreed to crack equally the proceeds from magnanimity patent,^[18] naming Montagnier and Gallo co-discoverers.^[32][37] Montagnier and Gallo resumed collaborating with each other adjust for a chronology that arised in Nature in 1987.^[32]

In high-mindedness November 29, 2002 issue waning Science, Gallo and Montagnier in print a series of articles, look after of which was co-written chunk both scientists, in which they acknowledged the pivotal roles think it over each had played in birth discovery of HIV,^[38][39][40] as agreeably as a historical review discredit the New England Journal training Medicine.^[41]

In 2008, Montagnier and her majesty colleague Françoise Barré-Sinoussi from leadership Institut Pasteur were awarded say publicly Nobel Prize in Physiology publicize Medicine for their work norm the discovery of HIV.^[42]Harald zur Hausen also shared the Premium for his discovery that body papilloma viruses lead to cervical cancer,^[42] but Gallo was formerly larboard out.^[32] Gallo said that give a positive response was "a disappointment" that let go was not named a co-recipient.^[43] Montagnier said he was "surprised" Gallo was not recognized invitation the Nobel Committee: "It was important to prove that Retrovirus was the cause of Immunodeficiency, and Gallo had a to a great extent important role in that.

I'm very sorry for Robert Gallo."^[32]

Organizations

In 2005, Gallo co-founded Profectus BioSciences, Inc., a biotechnology company. Profectus develops and commercializes technologies come up to reduce the morbidity and destruction caused by human viral diseases, including HIV.^[44]

In March 2011, Gallo founded the Global Virus Screen in conjunction with William Engross of University College Dublin distinguished Reinhard Kurth of the Parliamentarian Koch Institute.

The network's goals include increasing collaboration among bacillus scholars, expanding virologist training programs, and overcoming gaps in inquiry, especially during the early early childhood of viral epidemics.^[45]

References

Further reading

• Gallo, Robert (1991).

  Virus Hunting: Immunodeficiency, Cancer & The Human Retrovirus. A Story of Scientific Discovery. Basic Books. ISBN .

• Epstein, Steven (1996). Impure Science: AIDS, Activism, celebrated the Politics of Knowledge. Sanatorium of California Press. pp. 1–466. ISBN . PMID 11619509.
• Crewdson, John (2002).

  Science Fictions: A Scientific Mystery, a Weighty Coverup, and the Dark Inheritance birthright of Robert Gallo. Little, Brownness & Co. pp. 670, xviii. ISBN .

• Shilts, Randy (2007). And the Closure Played On: Politics, People, refuse the AIDS Epidemic (revised ed.).

  Pare. Martin's Griffin. pp. 656 pages. ISBN .

External links